The Laboratory of Jesse Engreitz (Dept of Genetics, BASE Initiative) are seeking a Research Scientist (Life Science Research Professional 3) focusing on human genetics, genome editing, and genomics to lead a project to understand the genetic basis of heart diseases. The Engreitz Laboatory is located in the Biomedical Innovations Building on the main campus at Stanford University and are members of the BASE Initiative in the Betty Irene Moore Children's Heart Center.

Project overview: DNA regulatory elements in the human genome, which harbor thousands of genetic risk variants for common and rare heart diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions -- if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes, and genes with thousaunds of pathways across the diverse cell types in the human body. We have recently developed new approaches that could enable mapping this regulatory wiring at massive scale (see Fulco et al. Science 2016, Fulco et al. Nat Genet 2019, Nasser et al. Nature 2021, Gschwind et al. bioRxiv 2023), and applied these and other approaches to understand the genetic basis of complex diseases (e.g., Schnitzler et al. Nature 2024). We have now identified enhancers that contain disease variants that affect risk for diverse cardiovascular diseases and traits, and aim to study the functions of these enhancers in human cellular models. These studies will ultimately help to uncover biological mechanisms of congenital heart defects, and help to guide diagnosis and treatment for children with heart disease. For information and recent work, see https://www.engreitzlab.org and https://med.stanford.edu/base.html

We are looking for a creative and passionate Research Scientist (PhD-level) to lead the next phase of our efforts to systematically perturb the genome to understand genome function and phenotype. The ideal candidate would lead independent projects, design and supervise large-scale CRISPR data generation projects, and contribute to managing collaborations between the Engreitz Lab and NIH-led consortia. The Engreitz Lab provides a dynamic, interdisciplinary workplace with unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of scientific contributions. We value a diversity of values, backgrounds, and approaches to solving problems.

The candidate for this position should have hands-on experience in cellular genomics, molecular biology, and technology development; experience with quantitative data analysis; curiosity in research and creativity in problem-solving; strong interpersonal and collaboration skills; experience building or managing teams; outstanding verbal and written communication abilities; ability to adapt to and effectively manage changes in a fast paced and dynamic environment; and have a passion for science and sense of urgency to find new medicines to benefit patients.

In addition to submitting your application via the Stanford web portal, please email your CV and cover letter directly to Prof. Jesse Engreitz ([email protected]).

Duties include:

• Make fundamental discoveries about gene regulation and the genetics of cardiovascular disease
• Together with PI and other lab members, design and execute scientific projects
• Develop and apply strategies to study enhancers and genes in human cells and mouse models
• Evaluate and recommend new emerging technologies, approaches, and problems
• Supervise, train, and collaborate with other lab members in experimental techniques, scientific design, and other skills
• Design and lead independent projects
• Collaborate with a team of experimentalists and computational biologists
• Create scientifically rigorous visualizations, communications, and presentations of results
• Contribute to generation of protocols, publications, and intellectual property

* - Other duties may also be assigned

The expected pay range for this position is $93,062.00 to $111,670.00 per annum. Stanford University provides pay ranges representing its good faith estimate of what the university reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location and external market pay for comparable jobs.

At Stanford University, base pay represents only one aspect of the comprehensive rewards package. The Cardinal at Work website (https://cardinalatwork.stanford.edu/benefits-rewards) provides detailed information on Stanford's extensive range of benefits and rewards offered to employees. Specifics about the rewards package for this position may be discussed during the hiring process.