An exciting opportunity has been created for an experienced researcher to join the Braun Laboratory at the OHSU Knight Cancer Institute as a Senior Research Associate in Portland, OR. The OHSU Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. Driven by its mission to end cancer as we know it, the institute is building upon its expertise in targeted treatments to advance the early detection of cancer when the disease is most treatable.
The primary goal of the Braun Laboratory is to understand how changes in the epigenome influence the development of blood cancers. We employ a variety of high sensitivity and single cell methods to understand how early oncogenic mutations alter the epigenetic landscape of developing blood cells driving progression to cancer.
Function/Duties of Position
Functions/Duties of Position:
This position will be focused on single cell genomics approaches to study minimal residual disease (MRD) in acute myeloid leukemia (AML) with the goal of developing improved assays to detect MRD and the comprehensive characterization of MRD cells with the goal of developing specific MRD-targeted therapy. This position will involve both laboratory and computational approaches and as such the ideal candidate will have expertise in cell/molecular biology laboratory techniques as well as fluency with the computational analysis of large datasets, expertise in R/python programing languages and familiarity with the molecular genetics of AML.
The position is in a collaborative, interdisciplinary, and highly translational environment in the OHSU Knight Cancer Institute and the Department of Hematology and Oncology in the OHSU School of Medicine. Highly-motivated candidates with expertise in molecular biology, hematopoiesis, and computational biology who are interested in a career in oncology basic/translational research will be most competitive for this position.
Additional responsibilities include, but are not limited to: maintaining a high level of professional expertise in the field; supervising and providing guidance and mentorship to other researchers within the laboratory; designing and directing or executing experiments; and establishing laboratory procedures and systems that enforce and maintain a high level of organization in the lab. The individual should have demonstrated success in leading, managing and participating in collaborative projects and a distinguished record of scientific and technical accomplishments.
Senior Research Associates have a PhD and 1 year of post-graduate research experience or a Master's degree and 5 years of experience in the relevant field. The Senior Research Associate oversees the design of research studies, procedures, and day to day operations in support of research goals and grant commitments. Monitors results, responds to unusual outcomes, develops and implements modifications to address any technical or design issues. Performs work of the highest difficulty using extensive knowledge in specialized field of study. With expert knowledge of research practices, directs and teaches others the methodology/ Standard Operating Procedures. Serves as a mentor to junior staff. May contribute significantly to grant proposals, author and coauthors publications, present at national conferences/ meetings. This individual should have the potential to lead the projects in the Braun lab. In order to maintain successful track record and show potential of growth, the individual must be actively engaged and leading projects that are aligned with the lab's focus area.
Duties will include:
1. Every Knight Cancer employee is expected to embody our guiding principles:
We act BOLDLY--Breakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
We SUPPORT each other--Respect leads to trust, which leads to excellence
We work as a CONNECTED team -- We must leverage our collective brain power to conquer cancer because no one individual can do it alone
2. Laboratory Research Project Management: Develop and manage research experiments, determining the most suitable methods to be used. Interpret and perform complex data analysis on experimental results and determine whether they are consistent with goals. Ensure that research team members maintain accurate and detailed records of all experimental procedures, data collections and analysis performed. Maintain a high level of professional expertise through familiarity with current scientific literature. As needed, develop innovative techniques and experimental systems to meet Braun laboratory research program goals.
3. Scientific Writing and Project Proposal Development: Prepare research findings for presentation at scientific meetings and conference and manuscripts for publication. Prepare research project proposals for internal and external review, prepare annual or bi-annual research progress summaries and presentations.
4. Scientific Project Oversight: With input from Dr. Braun, help to develop and oversee laboratory research projects including: identification of scientific problem, design of approach to address it, and identification, acquisition and management of resources to perform investigations. Provide training and guidance to postdoctoral fellows, clinical research fellows, graduate students and undergraduate students.
5. Collaborative Interactions: Develop, foster and maintain relationships with partners in academia and in the pharmaceutical/biotechnology industries. Oversee the advancement of milestones of funded projects and ensure that external partners receive regular project updates.
PhD in relevant field AND 1 year of relevant experience
OR Master's Degree in relevant field AND 5 years of relevant experience
OR Bachelor's Degree in relevant field AND 9 years of relevant experience
Expertise in cancer biology, molecular/hematopoiesis, and genomics, computational biology
Job Related Knowledge, Skills and Abilities (Competencies):
Proficient with computers specifically MS Office (which includes, Excel, Access, Word and PowerPoint) and statistical analysis software.
Strong publication record
Experience handling chemical and biologically hazardous materials.
Knowledge of policy and regulations applicable to the laboratory, including but not limited to safety, animal and radiation.
Technical proficiency, scientific creativity collaborative ability, and independent thinker
Proven ability to work collaboratively with a high performing work group
Ability to prioritize multiple tasks at one time
Must have excellent communication, analytical and organizational skills: both written and verbal.
Ability to work independently and as part of a team while being collaborative in resolving problems.
Demonstrated ability to learn new and innovative processed quickly
Must possess energy and drive to coordinate multiple projects simultaneously.
Ability to use tact and diplomacy to maintain effective working relationships
Ability to operate complex scientific equipment and develop and troubleshoot complex experimental protocols
Demonstrated ability to build productive cross functional collaborations both internally and externally
Ability to analyze short- and long-term project needs.
Ability to schedule, manage and coordinate multiple projects and priorities simultaneously
Please submit a resume and cover letter for your application to be considered.
Please note: As of Oct. 18, 2021, all OHSU employees are required to be fully vaccinated against COVID-19. Fully vaccinated means you have received both doses of a two-dose, or one dose of a single-dose, FDA- or WHO-authorized COVID-19 vaccine and at least 14 days have passed since your final dose of COVID-19 vaccine. If you apply for and are offered a position, you must be fully vaccinated prior to starting work.
If the position you are offered does not require direct, in-person patient care contact, you may request an exception to the vaccine policy for medical or religious reasons. OHSU uses very narrow criteria under the law to allow an exception and very few requests are being approved.
All are welcome
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or [email protected] As an organization devoted to the health and well-being of people in Oregon and beyond, OHSU requires its employees to be fully vaccinated against COVID-19.
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