A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
The Michigan Center for Translational Pathology (MCTP) has an open position for a Research Lab Specialist Associate. We are seeking an energetic, highly motivated individual to join our cancer biology and therapeutic group. The successful candidate is expected to thrive in a fast-paced dynamic environment. The candidate will work as part of a team screening small molecule inhibitors and performing functional validation for targeted therapy of cancer in vitro and in vivo. The candidate will perform routine laboratory experimental procedures in one or more areas of work under the supervision of the Principal Investigator and/or higher level research staff. The individual will perform these diverse duties as a member of a team of investigators.
Routine cell culture maintenance: passaging of adherent and suspension cells, freezing and recovering cell lines, and keep good record for cell line bank.
Develop and maintain primary cell culture from patients.
In vitro high throughput screening of small molecule: determine and calculation IC50 in 96 or 384 well formats.
Functional assay: perform protein, RNA and gDNA extraction from cells and tumor tissue, western blot, confocal microscopy slide preparation, qPCR, genotyping mouse colony.
Histology preparation: process fixed tissue, paraffin embedding, and microtome section.
In vivo work: basic mouse handling skills such as restraint of various strains of mice, ear tagging of young and adult mice; establish various tumor models such as tumor cell injection by subcutaneous, tail vein, intracardiac; tumor measuring through digital caliper or bioluminescent imaging; therapeutic drug preparation and dosing through different routes such as oral gavage, intraperitoneal, subcutaneous, tail vein, and retro orbital; perform animal necropsy and tissue/organ collection; maintain genetically modified mouse colony and genotyping; perform surgery on mice such as tumor implantation, tumor resection, and castration.
Assist to development new technique and assay when needed.
Maintain detailed records of bench work and in vivo work on notebook and online database.
Train and manage undergraduate research students.
Maintain lab equipment and organize sample inventory.
Draft and maintain lab protocol.
BS degree in cell/molecular biology or similar field.
At least one to three years wet bench lab research experience.
Experience in mammalian cell culture, nucleic acid and protein isolation, PCR, qPCR, western blotting.
Basic mouse handling skills.
Strong organizational and multi-tasking skills.
Excellent documentation skills for research results.
Excellent teamwork and communication skills.
Excellent time management skills.
Ability and willingness to learn and implement novel experimental techniques.
Knowledge and understanding of laboratory safety and ability to work carefully with potentially harmful agents.
Willing to have some schedule flexibility and occasionally work on weekends.
Ability to function independently as well as a team member in a team setting.
Cancer biology research lab experience.
Molecular biology research lab experience.
Animal surgery experience.
Strong writing and mathematics skills.
Strong troubleshooting ability.
Familiar with Microsoft office such as Word, Excel, and PowerPoint.
Familiar with GraphPad Prism.
Familiar with PubMed or other literature search portals.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
Internal Number: 193092
About University of Michigan - Ann Arbor
A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.