| Cold Spring Harbor Laboratory is seeking an experienced research scientist for an immediate opening as Assistant Director of the Mass Spectrometry Laboratory directed by Darryl Pappin. The successful candidate will broadly apply proteomics and protein chemistry approaches in basic research, including cancer, neuroscience, and plant biology fields. The person will play a critical role in executing technical protocols and laboratory experiments using established protocols. At the same time, a successful candidate will be able to contribute to the development of novel experimental designs, workflows, and new analytical methods. The successful candidate will join a vibrant group of innovative scientists in a world-renowned research community. The CSHL Mass Spectrometry group has broad expertise in various mass spectrometry applications, including protein identification, quantitative proteomics, metabolomics, phospholipid analysis, and redox proteomics. The group is led by Darryl Pappin, a world leader protein chemistry and proteomics, with a strong track record for technology and software development. The MASCOT search software and the isobaric iTRAQ chemistry were both developed in his laboratories. Under Pappin, the CSHL Mass Spectrometry group has contributed to a wide variety of discoveries in cancer and more fundamental biology. These include the first characterization of persulfide modifications of protein tyrosine phosphatases, the identification of a potential cancer therapeutic from wheat germ extract and characterization of a completely novel class of copper chelators. In cancer biology, contributions include discoveries in the redox biology of Nrf2, the role of the CA19-9 antigen in pancreatic cancer, and the mechanism of action of the PTEN tumor suppressor. The successful candidate will oversee day-to-day operations in the Mass Spectrometry Core, with responsibility for scheduling and tracking projects, and ensuring projects are completed in a timely fashion and with high quality. He/she will consult with customers to discuss the projects, including experimental design, troubleshooting strategies and data analysis. He/she will also be involved hands-on with protocol development and sample processing and analysis. The scientist will be expected to produce monthly and final reports to communicate progress on these projects. |
