Cold Spring Harbor Laboratory is seeking an experienced research scientist for an immediate opening as Assistant Director of the Mass Spectrometry Laboratory directed by Darryl Pappin. The successful candidate will broadly apply proteomics and protein chemistry approaches in basic research, including cancer, neuroscience, and plant biology fields. The person will play a critical role in executing technical protocols and laboratory experiments using established protocols. At the same time, a successful candidate will be able to contribute to the development of novel experimental designs, workflows, and new analytical methods.
The successful candidate will join a vibrant group of innovative scientists in a world-renowned research community. The CSHL Mass Spectrometry group has broad expertise in various mass spectrometry applications, including protein identification, quantitative proteomics, metabolomics, phospholipid analysis, and redox proteomics. The group is led by Darryl Pappin, a world leader protein chemistry and proteomics, with a strong track record for technology and software development. The MASCOT search software and the isobaric iTRAQ chemistry were both developed in his laboratories. Under Pappin, the CSHL Mass Spectrometry group has contributed to a wide variety of discoveries in cancer and more fundamental biology. These include the first characterization of persulfide modifications of protein tyrosine phosphatases, the identification of a potential cancer therapeutic from wheat germ extract and characterization of a completely novel class of copper chelators. In cancer biology, contributions include discoveries in the redox biology of Nrf2, the role of the CA19-9 antigen in pancreatic cancer, and the mechanism of action of the PTEN tumor suppressor.
The successful candidate will oversee day-to-day operations in the Mass Spectrometry Core, with responsibility for scheduling and tracking projects, and ensuring projects are completed in a timely fashion and with high quality. He/she will consult with customers to discuss the projects, including experimental design, troubleshooting strategies and data analysis. He/she will also be involved hands-on with protocol development and sample processing and analysis. The scientist will be expected to produce monthly and final reports to communicate progress on these projects.
Qualifications: Candidates should have a PhD in a scientific discipline, preferably in Biochemistry, Molecular Biology or related field. Applicants should have at least five years’ experience in the operation of mass spectrometers in the fields of either proteomics or protein chemistry, and preferably with at least three years’ experience in a proteomics core facility. Prior experience in the areas of general protein analysis and purification (e.g. HPLC, SDS-PAGE, enzymatic assays, Westerns, colorimetric assays, precipitations, etc.), cell culture and general laboratory techniques is required. Familiarity and skills with Mass Spec search engines and data analysis pipelines for quantitative proteomics is essential, preferably with demonstrated skills with SILAC, iTRAQ/TMT or label-free methods. Experience with other software packages such as SkyLine or Proteome Discoverer would be a plus. The successful candidate should be able to work effectively in a team while also independently planning and executing projects. Excellent project management and communication skills are also necessary.
We offer a comprehensive benefits package and competitive salary.
Please apply for this this position via the CSHL website: http://cshl.peopleadmin.com/postings/17162
Position Number: 01491-A
CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability or protected veteran status.
For more information about CSHL, please visit us at www.cshl.edu.
VEVRAA Federal Contractor
Internal Number: 01491
About Cold Spring Harbor Laboratory
Since 1890, Cold Spring Harbor Laboratory (CSHL) has been a global leader in research and education. The international scientific community at CSHL provides a unique and stimulating atmosphere for doctoral research?an environment where students, postdoctoral fellows, and faculty work side-by-side. The Watson School of Biological Sciences (WSBS) was founded on the belief that with well thought-out mechanisms, enthusiastic involvement of faculty, and highly motivated students, an innovative curriculum could be provided that would allow students to earn a doctoral degree in a shorter time than in traditional programs without compromising the quality of their training. The curriculum is designed to train students to become scholars and independent thinkers.