We seek a senior staff person to assume overall laboratory management of a team of 12 full-time staff (including technicians, postdoctoral fellows, and graduate students), several part time technical staff, and roughly six undergraduates. Lab management will include lab-specific protocol training, assuring regulatory compliance, and assisting in manuscript and grant preparation. This staff person also will oversee multiple research projects in concert with Dr. Largaespada as well as perform "hands on" lab research.
Lab management: overall 30% Strategic planning with Dr. Largaespada and senior staff: 5% Lab staff training in protocols: 5% Review of and assistance writing lab animal and biosafety protocols: 5% Literature review and teaching of lab members: 5% Grant and manuscript preparation and writing: 5% Identification of laboratory best practices and equipment: 5%
Specific project management and work: overall 70% This will involve identifying personnel, equipment, timelines, and methods to achieve the project goals. Added to this, "hands on work" on some of the projects will be required. In some cases this will be done in collaboration with lab staff. Techniques used will be transgenic mouse generation and use, tumor implantation, tissue culture, histopathology, biochemistry (e.g. western blotting), and molecular biology.
Studying the effects of perinatal folate level on peripheral nerve sheath tumor development: 20% Testing drug treatments on 3D in vitro models of peripheral nerve sheath tumors: 20% Discovering and validating synthetic lethal interactions with various tumor suppressor genes: 20% Discovery of molecular pathways involved in tumor evolution using Sleeping Beauty: 10%
Required Qualifications: Advanced degree, preferably in biological sciences, with 1 or more years of research training Bench laboratory experience including work with tissue culture cells, lentiviral transduction and site-directed mutagenesis Mouse colony management including weaning Mouse surgical and non-surgical procedures including intravenous injections and orthotopic tumor and pellet injection Lab management skills including training documentation (standard operating procedures), hiring, and review of data
Preferred Qualifications: Cancer biology experience Molecular biology including RNA/DNA isolation, PCR and rtPCR Familiarity with University or Medical School based regulatory committees including Animal Care and Use Committees and Institutional Biosafety Committee
Internal Number: 336113
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