Department: MED-Neurological Surgery Salary/Grade: EXS/6
The Research Lab Manager manages daily operations, monitors lab performance, analyzes and reviews results, and supervises development and implementation of new laboratory protocols. Assigns work and supervises lab personnel and reviews technical operations ensuring that all processes, protocols and procedures are quality controlled and functioning up to standards. Develops, implements, and administers budgets, grants, and administrative procedures. Co-authors scientific papers for presentation and publication and coordinates writing, submission and administration of grants.
The Department of Neurological Surgery at Northwestern University Feinberg School of Medicine is seeking an outstanding Research Lab Manager to join the R01-funded lab of Dr. Craig Horbinski, whose group investigates the significance of mutations in isocitrate dehydrogenase 1 on glioma behavior. Mutant IDH1 is a powerful prognostic marker in gliomas, but the reasons for this are incompletely understood. Current research in the Horbinski laboratory focuses on the effects of mutant IDH1, and its D-2-hydroxyglutarate (D2HG) product, on the tumor microenvironment. This includes the role of D2HG in promoting seizure activity, as well as its role in reducing thrombosis.
The Horbinski laboratory uses a wide variety of in vitro and in vivo techniques, including assays to test malignancy and blood clotting, metabolomics, next-generation sequencing, methylation profiling, patient-derived intracerebral xenografts, Sleeping Beauty models of IDH mutant gliomas, neuronal firing, and seizure activity in mice. We are located on the Northwestern Downtown Campus in the Chicago Streeterville neighborhood. This campus has state-of-the-art core facilities in the areas of genomics, metabolomics, proteomics, flow-cytometry and microscopy (http://www.feinberg.northwestern.edu/Research/cores/cores-list.html). Since Dr. Horbinski also directs the Northwestern Nervous System Tumor Bank and the Mouse Histology and Phenotyping Laboratory, his laboratory has excellent access to high-quality, patient-derived biospecimens and histologic assays for impactful research.
Manages technical operations of a lab involved in scientific research activities.
In consultation with Principle Investigator (PI), organizes and plans experiments ensuring those project objectives are attained.
Oversees and guides lab staff in review of results and recommendation of changes to protocols to improve validity and accuracy.
Conducts more complex experiments and analysis.
Using an advanced level of skill, completes the following activities (please highlight):
DNA, RNA, Protein isolation, purification and expression
Southern, Northern, Western blotting
Cell culture, cell isolation
Oversees and manages collection, maintenance, analysis and evaluation of data that will be used in grant submissions, presentations and publications.
Ensures that information is entered correctly into databases.
Assists PI in reviewing, analyzing, interpreting, summarizing, formatting, editing, and preparing tables, charts, graphs, progress and final reports, etc.
Coordinates between sponsoring agencies, collaboration organizations and/or other research and/or educational institutions.
Ensures research regulations are adhered to, IRB and ACUC approvals in place, material transfer agreements properly executed, and that radiation and lab safety requirements are up to date and implemented.
Manages lab budget and inventory including purchasing of supplies and services ensuring that they are necessary, reasonable and project related.
Orders and maintains inventory of lab supplies, chemicals, equipment and instrumentation and may distribute intra-departmental charges.
Negotiates with vendors, obtain quotes and arrange for demos of large equipment.
Trains, directs, assigns duties to & supervises lab EEs, students, residents &/or fellows.
Provides instruction to lab users on technically complex procedures, equipment & instruments.
Typically manages a lab budget of $1,000,000-$3,000,000; 1,000 - 3,000 nasf of space & supervises 5-15 lab members.
Other duties as assigned.
Successful completion of a full 4-year course of study in an accredited college or university leading to a bachelor's or higher degree in a scientific major or related; OR appropriate combination of education and experience and 6 years' lab/bench or other relevant experience required; OR
Successful completion of a full course of study in an accredited college or university leading to a master's or higher degree in a scientific major or related; OR appropriate combination of education and experience and 4 years' lab/bench or other relevant experience.
Supervisory or project management experience required.
Bachelor of Science in biological sciences combined with a minimum of 4 years related research laboratory experience OR Master’s degree in biological sciences combined with a minimum of 2 years of related research laboratory experience.
Experience handling patient tissues and blood, and awareness of Universal Precautions.
Preferred Competencies: (Skills, knowledge, and abilities)
Working knowledge and application of IACUC/NSIS regulatory issues.
Knowledge of cancer biology.
Meticulous attention to detail.
Demonstrated computer proficiency, including spreadsheets, database, and basic computations (specifically Microsoft Office Word, Excel, PowerPoint).
Precise and accurate record keeping.
Ability to work independently and in a team environment.
Strong written and verbal communication skills.
Ability to build rapport with members of multidisciplinary teams.
Knowledge of IACUC procedures and preparing new animal protocols for IACUC approval.
Strong planning, organization and time management skills are necessary
Northwestern University is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities. Women, racial and ethnic minorities, individuals with disabilities, and veterans are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.
Internal Number: 38518
About Northwestern University
Northwestern University is a major private research university with 12 academic divisions located on three campuses in Evanston, Chicago, and Education City in Doha, Qatar. We have approximately 2,500 full-time faculty members, 17,000 graduate and undergraduate students, and over 5,700 full and part-time staff. Northwestern University combines innovative teaching and pioneering research in a highly collaborative environment. It provides students and faculty exceptional opportunities for intellectual, personal and professional growth.