Responsible for the daily management of a high-throughput lab that performs research based and clinical genotyping and sequencing. In conjunction with co-managers, responsible for supervising, coordinating and directing all activities of the laboratory to achieve goals and objectives set with senior staff. Responsible for work product of a staff of approximately 13 technicians who process ~100,000 genotyping samples and ~10,000 sequencing samples per year. Effective production and sample management requires coordination with all other units at CIDR including administration, project management, informatics, technology evaluation and data analysis.
Individually responsible for lab management duties related to multiple ongoing custom and fixed format SNP genotyping and sequencing service projects which are assigned on a rotating basis.
Responsible for weekly lab progress reports to Laboratory Director and Assistant Laboratory Director.
Identify and present lab-wide issues and propose solutions.
Present supporting experimental data when appropriate.
Independently design appropriate experiments and direct their execution by research technicians and/or laboratory technicians.
Involve and coordinate informatics, project management, technology evaluation and statistical genetics staff in experimental design and analysis where appropriate.
Participate in planning future improvements to meet the constantly increasing and changing demands of the genetics community.
Examples of involvement include:
transfer and integrate new technologies and methods from research and development department to production lab
design, integrate, and test new information management systems for handling production genotyping data
participate in decisions about major equipment purchases for laboratory
participate in decisions regarding reorganization of personnel structure and job responsibilities in the lab including personnel policy
Responsible for the development of technical and personnel operational policies and procedures, and ensuring adherence to such policies and procedures
Identify and test new or alternative products and/or instrumentation for utility in lab as they become available.
Make recommendations to Director addressing cost and quality comparison to current methods.
Responsible for hiring and supervising all production lab personnel in conjunction with co-managers.
Ensure that all staff receives appropriate orientation, training, and performance evaluations.
Responsible for organization and scheduling of daily workflow and instrument time schedules in the genotyping and sequencing production lab.
Rely on Lab Team Coordinators for assistance with recruiting, interviewing and hiring as well as training all new production lab technicians.
Establish up-to-date written laboratory protocols.
Maintain safety records and assure lab staff are trained and proficient in the use of universal precautions and general safe laboratory procedures Provide supervision and direction to staff to facilitate achievement of goals.
Monitor compliance with established goals.
Troubleshoot and solve all daily laboratory problems for technicians in conjunction with Lab Team Coordinators and Lab QC Analysts.
Responsible for QA/QC of all data produced by subordinate lab staff.
One of the following three areas of overall responsibility for the entire production genotyping service laboratory (~15 staff, ~100,000 samples per year) will be permanently assigned: Able to serve and backup in other two areas.
Serve as primary contact with human resources for opening of positions in the laboratory and coordinating with human resources to identify candidates, facilitate their interview process and coordinate their hiring process within CIDR.
Review and edit job descriptions as needed.
Maintain service/maintenance records on all lab instrumentation.
Train all personnel as needed in maintenance of lab instrumentation.
Place instrument service calls and assure all required repair and maintenance is completed in a timely fashion.
Work with administrative staff to ensure maintenance contracts are renewed.
Responsible for being the main contact for requests for software development to the programming team.
Responsible for testing of all software developed in-house and for ensuring it is working properly.
Responsible for ensuring all staff are notified of changes and are trained properly on new software.
Additional duties as needed.
Bachelor’s degree in biology, chemistry or related field.
Five (5) years of related experience required. Proven technical knowledge and laboratory experience.
Master's degree, with related graduate research, may substitute for experience to the extent permitted by the JHU equivalency formula.
JHU Equivalency Formula: 18 graduate degree credits may substitute for one year of experience. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.
Master’s degree in related field, or equivalent years of progressively more responsible experience in the field of genotyping.
Production-scale genotyping experience preferred.
Special Knowledge, Skills, and Abilities:
Thorough knowledge of molecular biology theory and practice.
Work requires a high level of analytical ability to solve complex technical problems.
Experience with Illumina BeadLab equipment, Illumina HiSeq, Illumina GoldenGate and Infinium chemistries and Agilent chemistries.
Proven ability to work with informatics personnel in the design and testing of custom software is required.
Basic understanding of NT and UNIX operating systems required.
Relational database experience including writing SQL queries required.
Experience with Microsoft Excel spreadsheets required.
Classified title: Laboratory Manager
Working title: Laboratory Manager
Role/Level/Range: ACRP 37.5/E/04/MD
Starting Salary Range: $52,494.96 – $72,212.64 (commensurate with experience)
Location: Suite 200 - 1812 Ashland Ave, Baltimore, MD
Department name: 10002884-SOM Genetics Ctr for Inhrtd Dis Res CIDR
Personnel area (School): SOM – School of Medicine
The successful candidate(s) for this position will be subject to a pre-employment background check.
If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the HR Business Services Office at [email protected]. For TTY users, call via Maryland Relay or dial 711.
The following additional provisions may apply depending on which campus you will work. Your recruiter will advise accordingly.
During the Influenza ("the flu") season, as a condition of employment, The Johns Hopkins Institutions require all employees who provide ongoing services to patients or work in patient care or clinical care areas to have an annual influenza vaccination or possess an approved medical or religious exception. Failure to meet this requirement may result in termination of employment.
The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.
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