The Sr. Research Specialist will develop, conduct and evaluate scientific research in a laboratory. Will have an in-depth understanding of the context and implications of the research in order to apply and interpret theoretical knowledge necessary to conduct research. The range of duties includes, but is not limited to: project planning, experimental design, developing methodology, conducting procedures, modifying procedures as needed, data collection and analysis, laboratory management, project management.
Specific Duties & Responsibilities:
Makes intellectual contributions with the collaboration of the PI. Makes independent decisions that may alter research outcomes and objectives.
The main research fields are molecular genetics, proteomics and physiological assays in multiple models of cardiovascular diseases.
Performs high throughput proteomic experiments with biological fluids/tissue by utilizing liquid chromatograph (LC, such as HPLC, PF2D), electrophoresis and immune assays.
Performs sophisticated analyses of animal models of cardiac and skeletal muscle disease and knowledge of varied methods.
Will collaborate with others on the development new technologies, protocols, and equipment.
Works independently with minimal supervision. Participates in the design of experiments and evaluating/interpreting results.
Selects, develops, performs and evaluates research methods. Develops, design, and manage research projects with the ability to coordinate their own objectives.
Maintains inventory levels and monitors storage of materials and supplies in accordance with established policies.
Responsible for the maintenance of light and confocal microscopes for fly and mouse husbandry and colony/stock maintenance.
Works on immunoassays involves assay design, antibody testing, as well as determining specificity, sensitivity.
Will be required to write peer reviewed manuscripts and grants. Will also be the co-author on publications while contributing thoughts, hypotheses, and analysis for papers, abstracts, and manuscripts.
Independently perform in the lab on all research assays specific to genomics, proteomics and muscle function. Will provide directions to other staff, students, and will have evaluation feedback.
Enhance problem solving through interactions and collaboration with senior researchers at meetings and or professional presentations.
Minimum Qualifications (mandatory):
Required: BS/BA, or equivalent, in biology, molecular biology, chemistry, protein chemistry or a related field required.
Preferred: MS preferred.
Four years post-undergraduate experience in a comparable laboratory required. Require functional knowledge in protein separation and muscle physiology.
Proficiency in Drosophila molecular genetics and standard molecular biology techniques strongly preferred.
Special Knowledge, Skills, and Abilities:
Experience in gel electrophoresis, HPLC or FPLC plus.
Previous experience in proteomics, clinical proteomics and biomarker field plus.
Experience in 2-dimentional electrophoresis, Western blotting, immune assay (ELISA), chromatography and mass spectrometry plus but not required.
Experience with light and confocal microscopy maintenance and imaging a plus.
Proficiency in Drosophila molecular genetics and standard molecular biology techniques preferred.
Adept in striated muscle physiology and physiological concepts; experience in confocal and digital video light microscopy helpful.
Classified Title: Sr. Research Specialist Working Title: Sr. Research Specialist Role/Level/Range: ACRP/04/MC Starting Salary Range: $45,195-$62,225 Employee group: Full Time Schedule: Monday-Friday/37.5 hours Exempt Status: Exempt Location: 04-MD:School of Medicine Campus Department name: 10002805-SOM DOM Cardiology Personnel area: School of Medicine
The successful candidate(s) for this position will be subject to a pre-employment background check.
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