Next review date:Tuesday, Jan 28, 2020 at 11:59pm (Pacific Time) Apply by this date to ensure full consideration by the committee.
Final date: Thursday, Feb 13, 2020 at 11:59pm (Pacific Time) Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
Project Scientist - High-throughput Screening - California Institute for Quantitative Biosciences - Core Facility
DESCRIPTION The California Institute for Quantitative Biosciences at the University of California, Berkeley High-throughput Screening Facility (QB3-HTSF) seeks applications for a Project Scientist at 50% (part-time) with an anticipated start date in January 2020. The Project Scientist will provide consulting services in the area of high-throughput screening and seek out their own collaborative research projects and supportive funding. The position encompasses project development and management, implementation, and contributions to reporting of results by presentations or manuscript submissions. A research background in high-throughput/high-content confocal imaging projects involving genomic screening (siRNA, CRISPR/Cas9 or other) or other multi-conditional phenotypic/morphological screens is highly desired. The Project Scientist will advance projects through contribution of their own expertise, especially in the area of cell-based assay development, automated microscope set up optimization, and image analysis. The Project Scientist's expert assistance will expedite the significant downstream data-intensive post-imaging steps that include image analysis, HT/HC screening QC assessment, and data visualization (bio-imaging informatics). The activities of the Project Scientist will advance QB3-HTSF's capabilities and PI projects.
In a secondary role, a successful candidate will also help support our flagship automated microscope, the Opera Phenix by Perkin Elmer, with training, and aiding researcher implementation of their project pipelines along with work on their own independent projects. The candidate will take a supporting or lead role on outreach of the HTSF, such as HTS/HCS user group meetings, conference talks, or departmental retreats as a way to cultivate new relationships for collaborative projects that the Project Scientist can be involved in.
Project Scientist, Development and Project Management
o Develop project plans in collaboration with PIs that will cover the Project Scientist's independent or collaborative medium scope projects that benefit both the PI and the HTSF (Grant research aims and facility development). Implementation will include project and HTSF junior staff management, creating reports and presenting result updates to the researchers and PIs, as well as hands-on work to fulfill the project plan aims. o Develop project plans with outside users including start-up company clients to describe the work to be done for their project by either company staff or by HTSF staff including the Project Scientist, this project plan will go into the UCB Business Contracts and/or Brand Protection access/service contract. Implementation will include project and HTSF junior staff management, creating reports and presenting result updates to the clients, as well as hands-on work to fulfill the project plan. o Develop and manage project plans to work with PIs or start-up company clients for the HTSF to perform entire screens or other large scope projects at the HTSF, including all processes such as assay optimization decisions, development of high-content analysis development, and quality control assessment. Implementation of these solely service projects will include project and HTSF junior staff management, creating reports and presenting result updates to the PIs or start-up company clients, as well as hands-on work to fulfill the project plans.. o Participate in identifying funding opportunities and in manuscript writing as a contributing author with the PI.
HTSF Operation: o Work closely with our current HTSF team of director, automation manager, IT expert, and HTSF junior staff to coordinate independent project implementation . o Oversee the operation of the Opera Phenix automated confocal imager and analysis pipeline. o Understand and use the HTSF's liquid handling automation pipeline and instrumentation that may be required for independent project implementation o Monitor computer and network related issues and coordination troubleshooting and improvements with IT. o Work with researchers (35+) to ensure that planning, training, execution, and follow-up of screens are within the researcher's time requirements and specifications. o Keep HTSF supervisor informed of current priorities, lab issues and keep a notebook of daily work, issues, and research results. Utilize iLab scheduling/permissions software to schedule their independent project use on instruments and/or computer workstation, as well as allowing researchers access to instruments once they have been trained on the automated microscope sufficiently.
BASIC QUALIFICATIONS (AT THE TIME OF APPLICATION)
PhD or equivalent international degree
ADDITIONAL QUALIFICATIONS (BY START DATE)
Five (5) years of research experience in a lab setting.
PhD or equivalent international degree in Biology, Chemistry, Chemical Engineering or related field
At least two (2) years of experience in cellular high-throughput assay development.
At least two (2) years of experience with BSL-2 engineering control adherence and proper PPE and waste disposal procedures.
At least one (1) year of experience with automated imagers from at least one commercial vendor such as Molecular Devices, ThermoFisher, or Perkin Elmer.
Demonstrated program development success.
Demonstrated understanding of fluorescent biomarkers and the optimizations needed for successful HT/HC cell-based assay screening.
Execution and completion of a cell-based genomic siRNA or other high-throughput and/or high content screen of at least medium size (1000 - 10000 different conditions in 96-well or higher multiwall plates)
Experience programming with one of the following image analysis software packages (or equivalent)
Interested individuals should submit application documents as PDFs as the following materials are required:
Contact information for three (3) references; two (2) optional.
Letters of reference are not required at this time. We will seek your permission before contacting your references. All letters will be treated as confidential per University of California policy and California state law. Please refer potential referees, including when letters are provided via a third party (i.e., dossier service or career center), to the UC Berkeley statement of confidentiality: http://apo.berkeley.edu/evalltr.html.
This recruitment will remain open until filled.
Specific questions regarding the recruitment can be directed to Jose Padilla, HR Partner, [email protected]
All letters will be treated as confidential per University of California policy and California state law. Please refer potential referees, including when letters are provided via a third party (i.e., dossier service or career center), to the UC Berkeley statement of confidentiality (http://apo.berkeley.edu/evalltr.html) prior to submitting their letters. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct.
The Department is interested in candidates who will contribute to diversity and equal opportunity in higher education through their research or teaching. The University of California, Berkeley has an excellent benefits package as well as a number of policies and programs in place to support employees as they balance work and family.
Curriculum Vitae - Your most recently updated C.V.
Statement of Research - One-page summary of research interests
3-5 required (contact information only)
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