The Vaccine and Gene Therapy Institute (VGTI) at Oregon Health & Science University (OHSU) has assembled a multidisciplinary team of scientists to respond to serious viral disease threats, including AIDS, chronic viral infection-associated diseases, newly emerging viral diseases and infectious diseases of the elderly. Our programs are intended to span the continuum between basic and clinical science, in which discoveries are rapidly advanced from the level of molecular and cellular biology through animal models and ultimately into clinical testing. The development of this unique program in immunology and virology provides an important training opportunity for graduate students and postdoctoral fellows at OHSU. This is why an important part of our mission is the training of young scientists in newer academic disciplines emerging at the Vaccine and Gene Therapy Institute.
We are a large nonhuman primate (NHP) researchprogram at the Vaccine and Gene Therapy Institute (VGTI) focused on 1) the collaborative development of cytomegalovirus (CMV)-based vaccine vectors for prevention and treatment of infectious and neoplastic diseases of global importance, including (in rough order of emphasis) HIV/AIDS, tuberculosis, malaria, Hepatitis B, influenza and prostate cancer, and 2) the development of novelapproaches (both vaccine and non-vaccine) to cure established HIV/SIV infection. To facilitate our goals the research group is comprised of faculty level Program Managers as well as an Administrative Support Group which includes a Laboratory Manager, Project Administrator (budget and compliance) and support staff for administrative duties, supply, procurement, reagent and inventory management, as well as a dedicated Flow Cytometry Group which supports the research focuses described below. Of note, our group interacts on a daily basis with the NHP Pathology Lab and the Infectious Disease Resource (IDR), and closely collaborates with other VGTI labs.
Vaccine Development Program (Prevention) The primary goal of this group is to continue to improve, understand and characterize recombinant CMV vectors for clinical translation. To accomplish this goal, the group is comprised of three primary Focus Groups including: 1) pre-clinical vaccine development and efficacy using the NHP model, 2) CMV immunobiology using molecular techniques, and 3) clinical translation. Each Focus Group is led by a senior technician ( Focus Supervisor ).Focus Supervisors are supported by Focus Leads that assist in coordinating daily operations and management of technical staff (Research Assistants).
HIV Latency Disruption and Immunotherapy Program (Cure) The focus of this group has been to delineate the mechanisms of SIV pathogenesis in the rhesus macaque model and to understand the cellular and immunological factors that contribute to viral persistence during conditions of optimal immunologic or pharmacologic control.Building on these discoveries, this group has expanded their efforts to include the development and testing of novel therapeutic strategies aimed at achieving eradicative cure or long-term remission from HIV/SIV replication after treatment interruption. Therefore, the primary goal of this group is to continueto develop novel strategies aimed at eliminatinglatently-infected cells with the goal of facilitating remission from HIV/SIV replication after cART cessation.To accomplish this goal, his laboratory is comprised of two primary Focus Groups including: 1) HIV latency disruption and 2) HIV Immunotherapy. Both groups are managed by a Focus Supervisor and supported by technical staff.
Technical staff (Research Assistants) within all Focus groups will be expected to carry out the science associated with various projects and provide the technical support required to meet the programs research objectives.Technical staff are expected to function independently or as part of a team to ensure all project goals are met.All staff are expected to carry out daily activities of the laboratory, including but not limited to: maintain detailed documentation of the experimental work (digital and physical records); ensure quality control of equipment, reagents and cellular material; work closely with lab members and with outside collaborators; perform and assist with experiments involving cell isolation, immunologic assays, microscopy, flow cytometry, and molecular biology; and maintain close communication with a supervisor regarding progress.The position will involve handling and processing human and non-human primate samples that may contain infectious agents.
Bachelors Degree (4 yr.) with major courses in field of research/No Experience or AA (2 yr.) and 3 years of relevant experience OR AA (2r.) and 3 years of relevant experience
Must be comfortable using computers (Mac, PC)
Willingness to work with pathogens potentially dangerous to humans
Willingness to work in Biosafety Level 2, 2+ and 3 facilities
Willingness and ability to work flexible hours (possibly including nights and weekends)
Ability and willingness to work independently
Ability to carry and lift 35-50lbs.
Ability to stand for five to eighthours a day
Ability to work on computer for five continuous hours a day
Ability to work 4-6 hours using a Powered Air Purifying Respirator (PAPR) and/or N95 respirator
Ability to work on a computer up to 8 hours a day
Employees may be required to be vaccinated with, but not limited to the following (compliance is required for employment):Hepatitis B, Smallpox Vaccine, and Tetanus
A TB screen with occupational health will be required every 6 to 12 months
Able to perform the essential functions of the position with or without accommodation
One year of experience
Laboratory experience, especially in sample processing
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or [email protected]
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and research. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide... many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm