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Posted Job Title
Sr. Research Investigator
Job Profile Title
Research Investigator, Senior
Job Description Summary
The Research Investigator Sr (SRI) will act in a leadership role, overseeing and designing advanced experiments. The Simpkins Laboratory has developed a unique, state of the art, patient-derived xenograft (PDX) experimental platform for NIH and industry sponsored evaluation of new drugs for the treatment of ovarian cancer. The ultimate goal of the laboratory is to identify scientifically rational drug combinations at the bench and move them into the clinic for women with ovarian cancer. The Simpkins Lab seeks an individual with a PhD, and extensive background in molecular/cellular biology and background in bioinformatics preferred but not required. Seeking an individual who has the experience to conduct their own project independently. The candidate alongside with the PI and lab manager, should be able to oversee the labs research projects, manage scientific collaborations, assist in writing scientific manuscripts and grant submissions.
The Simpkins laboratory in the Ovarian Cancer Center has the goal to identify novel therapies in the lab and bring them to the clinic for the treatment of ovarian cancer.
The Research Investigator Sr (SRI) will carry out his/her own projects with independence and timely submission of results for publication. The candidate must demonstrate the ability to analyze and present data in professional "publication ready" format and to able to independently prepare and write manuscripts and grants for submission. The candidate will serve as a lead on his/her own projects and contribute scientifically to other Simpkins lab projects. Candidate should be able to give scientific direction to postdoctoral fellows and technicians in the lab. The candidate will assist Dr. Simpkins in the scientific oversight of ongoing projects within the lab and assist with scientific collaborations with colleagues outside of the laboratory (including industry). The candidate will work closely with Dr. Simpkins and the lab manager to make sure the Simkpins lab is productive and runs efficiently. The candidate should have extensive experience in cellular/molecular biology. Candidate should have experience in preparing protein lysates, western bloting, FACS, transfection/transduction, and PCR are required. Responsibilities will also include establishing and growing primary tumor cultures, performing
invitro protein assays. SRI will be testing cells with a multi-compound drug-screen.
The candidate should have good communication skills, and be proficient in communicating and writing in English. Candidate should support a team approach to research and work well with other lab members. Must have experience writing and submitting scientific manuscripts.
. Qualifications The minimum of a PhD. and 5 years of experience working in a laboratory.
Experience in tissue culture such as growing human primary cells, ability to transfect/transduce cells, ability to perform western blots, and flow cytometry. Should be able to perform DNA/RNA analysis
Experience with DNA damage, fiber/combing preferred. Experience in bioinformatics analysis, (RNA, ATAC, DNA sequencing analysis) is preferred. Ability to trouble shoot is required. Ability to maintain organized laboratory data.
Must be flexible, able to work well with others and is a team player. Must be flexible with work hours.
Position is contingent upon funding.
Job Location - City, State
Department / School
Perelman School of Medicine
$32,000.00 - $204,000.00
Affirmative Action Statement Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
Internal Number: JR00013483
About University of Pennsylvania
Penn has a long and proud tradition of intellectual rigor and pursuit of innovative knowledge, begun by Benjamin Franklin in 1740. That tradition lives today through the creativity, entrepreneurship, and engagement of our faculty, students, and staff. Academic life at Penn is unparalleled, with an undergraduate student body of 10,000 from every U.S. state and around the world. The entering class of 2015 is the most talented and diverse in Penn's history. Consistently ranked among the top 10 universities in the country, Penn welcomes an additional 10,000 students to our top-ranked graduate and professional schools.