1) The Technical Director will lead the Breast Program Biospecimen and Preclinical Animal Models Core as an integrated infrastructure designed to support characterization of bio-specimens from individuals evaluated or treated for specific health conditions related to cancer at the University of Chicago, and to generate a living bio-repository of organoids cultured from relevant cancer and normal tissue.
2) He/She will be responsible for supporting a multi-component project effort and complex translational research studies that require development, establishment and characterization of cost-efficient, high-throughput tissue-based cancer models to recapitulate the disease in preclinical settings.
3) The Technical Director will work with research project team leaders, clinical coordinators, lab operational managers, Genomics, Analytic and Informatics Core leaders to ensure efficient and highly coordinated procurement of human bio-specimens to generate, analyze, characterize and cryopreserve cell lines and organoid samples, and will manage the maintenance of the organoid repository to be available as a preclinical model for cancer research.
4) He/She will ensure projects are managed in a timely and efficient manner and are appropriately documented.
5) The strategic procurement of these resources will provide The University of Chicago investigators and collaborative institutions with sample cohorts necessary to conduct biomedical research studies dedicated to advance preventative, diagnostic and therapeutic approaches for personalized risk prediction and better outcomes.
6) Oversee the tissue accrual as well as generation, characterization and cryopreservation of cell lines, organoids and animal models using state-of-the-art biological tools and methods.
7) Work effectively with the faculty, clinical coordinators, data analysts and researchers, to implement novel or adapt existing approaches for establishment and characterization of the core
8) Lead the development of the organoid model or the customization of existing models to meet specific scientific project needs
9) Identify suitable resources required for each project or particular research questions
10) Ensure compliance of research activities with institutional, state, and federal regulatory policies, procedures, directives and mandates.
11) Develop long-range plans for research projects and oversees the development of research projects. Ensures research projects progress according to plan.
12) Manage grant/funding applications. Establishes, monitors, and controls project budgets.
13) Manage, investigate, modify and apply new procedures, techniques or applications of technology. Oversees the establishment of goals and operating procedures, practices, and guidelines. Develops research in area of expertise. Writes articles, reports and manuscripts. Presents research findings at meetings and/or conference.
14) Stays up-to-date on new advances and developments in pre-clinical models for cancer research Â and provides on-demand support to various teams
15) Leads all necessary trainings related to tissue procurement,Â organoid model development and characterization, regulatory documentation, biobank management
1) Team leadership.
2) Project management and supervising skills.
3) Experience managing multiple research projects.
4) Advanced knowledge in relevant scientific field.
5) Advanced knowledge of research techniques and methods relevant to animal models, bio-specimen handling, including expertise with primary tissue, 3D culture and organoids.
6) Advanced knowledge of scientific applications and equipment relevant to tissue characterization including histology, gene expression, sequencing, microscopy, FACS.
7) Experience with preclinical model development and its application in preclinical studies (cell lines, organoids, and animal models).
8) Knowledge of regulatory policies and procedures for research projects and clinical studies conducted with samples of human origin.
9) Strong analytical skills.
10) Independent problem-solving and troubleshooting skills.
11) Strong verbal and written communication skills.
12) Ability to work independently while sustaining a collaborative environment.
13) Broad knowledge of Microsoft Office, database management and other applicable data analysis software.
1) Advanced degree in biology, biochemistry or related field
1)10+ years of relevant research experience in an academic environment or biomedical research setting
2) Cover letter
Note: When applying, all required documents MUST be uploaded under the Resume/CV section of the application.
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