JGI & Berkeley Lab: A View to Fuel Innovative Science in the Public Interest
They say it's all about location and Berkeley Lab has it all: a view above the San Francisco Bay, cool breezes, and world-class multidisciplinary science within a diverse and respectful research ecosystem of 5,000 people. Nearly 90 years ago, Ernest Orlando Lawrence, the inventor of the cyclotron, brought physicists, biologists, engineers and mathematicians together in Berkeley above the University of California campus to tackle the most urgent scientific challenges. Today, after garnering 13 Nobel Prizes, Berkeley Lab has sustained and grown that tradition of open, interdisciplinary team science, exemplified by how the U.S. Department of Energy Joint Genome Institute (JGI) addresses the most pressing energy and environmental challenges using integrative genome science approaches. JGI takes up residence in the new, state-of-the-art Integrative Genomics Building (IGB) along with the U.S. Department of Energy Systems Biology Knowledgebase (KBase) to expand the frontiers of energy and environmental science in partnership with the worldwide community of researchers. Will you join us and be a critical part of our next ground-breaking discoveries?
Under general supervision, this position will be responsible for designing and conducting complex experimental procedures to developing new strain engineering tools and approaches for bacteria, fungi, and algae. The individual will apply advanced molecular biology technologies and knowledge to develop a generalizable method to domesticate and engineer bacteria from environmental microbiomes for a number of DOE relevant applications. Will provide direction and guidance for team members to expand the existing bacterial host-engineering project to cover all major phyla. Will develop a high throughput approach of interrogating gene function in various hosts using the CRISPR-Cas9 genome editing tools. Will lead research and development and test novel strain engineering procedures, conduct troubleshooting, and prepare SOPs and transition the developed technologies to other team members. Position will interact with personnel in the Synthetic Biology, Instrumentation, Data Analysis, Metabolomics, and Secondary metabolite groups to validate and implement newly developed procedures. The position reports to the Functional Genomics group lead.
The JGI is comprised of highly-skilled and diverse talent founded on a culture of scientific excellence, trust, curiosity, passion, and collaboration that drives our desire to advance scientific frontiers and make bold new discoveries with our users.
Working at Berkeley Lab has many rewards including a competitive compensation program, excellent health and welfare programs, a retirement program that is second to none, and outstanding employee development opportunities. To view information about the many rewards that are offered at Berkeley Lab- Click Here.
What You Will Do:
Research and Development
Perform research and development oversight for key strain engineering projects.
Lead the design and construction of molecular DNA tools to perform microbiome engineering.
Participate in the development of high throughput functional genomics approaches for both internal as well as collaborative projects.
Search public databases and gather resources needed to perform the assigned projects
Lead troubleshooting efforts including projects performed by other team members, and provide timely guidance and expertise including re-design if necessary.
Analyze experimental results, generate reports, and present technical findings and project stats at regular group meetings.
Adopt new techniques and approaches into general workflows and when they become available
Closely collaborate with DNA synthesis staff and enter all strain engineering constructs into the sample repositories (ICE) for storage and seamless sharing of genetic tools.
Collaborate with informatics and data analysis staff to develop new and improved host range tools.
Attend and present findings at internal/external meetings and conferences.
Assemble and publish experimental results in peer-reviewed journals.
Perform quality control of laboratory procedures, equipment and robotics.
Implementation of New Processes
Write and update SOPs to describe the experimental procedures and areas of improvement conducive with a safe working environment.
Interact with the Instrumentation support group and provide recommendations for the design and implementation of new processes.
Lead efforts in the implementation of newly improved processes.
Provide technical guidance and training of laboratory procedures to other technical employees.
Troubleshoot and recommend approaches to address low quality issues.
What is Required:
Masters degree preferred and three to six years experience in independent project design, execution and data analysis.
Extensive experience in the advanced molecular cloning and transformation of bacteria, fungi, and algae.
Substantial knowledge and skills in Synthetic Biology, vector design, sequence analysis.
Demonstrated knowledge and skills in the area of genome editing and functional genomics.
Expertise in the use and application of DNA construct design tools (BioCAD).
Strong written and oral communication skills
Demonstrated skills in effective project management including scheduling and reporting, as well as the ability to guide and collaborate with multiple team members.
Strong understandings of how scientific principles are applied to the problem being studied.
Experience in complex protocol development and optimization procedures.
Strong analytical, record-keeping and organization skills necessary for working in a laboratory environment.
Effective interpersonal skills necessary for working in a diverse team environment.
Demonstrated ability to work independently and as an active team leader in a group effort.
Additional Desired Qualifications:
Ph.D. or MS in Biology, Molecular Biology, Biochemistry, Genetics, or related field or an equivalent combination of education and experience
Experience with automated liquid handling systems.
Experience in working with large DNA molecules.
Knowledge of state-of-the art laboratory instruments.
The posting shall remain open until the position is filled.
This is a full-time career appointment.
Full-time, M-F, exempt (monthly paid) from overtime pay.
This position is represented by a union for collective bargaining purposes.
Salary will be determined based on the range by the collective bargaining agreement.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at DOE Joint Genome Institute (JGI) -- 1 Cyclotron Road, Berkeley, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."
Internal Number: 88626
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.