JGI & Berkeley Lab: A View to Fuel Innovative Science in the Public Interest
They say it's all about location and Berkeley Lab has it all: a view above the San Francisco Bay, cool breezes, and world-class science within a diverse, respectful research ecosystem of 5,000 people. Nearly 90 years ago, Ernest Orlando Lawrence, the inventor of the cyclotron, brought physicists, biologists, engineers and mathematicians together in Berkeley above the University of California campus to tackle the most urgent scientific challenges. Today, after garnering 13 Nobel Prizes, Berkeley Lab has sustained and grown that tradition of open, interdisciplinary team science, exemplified by how the U.S. Department of Energy Joint Institute (JGI) addresses the most pressing energy and environmental challenges. This summer, JGI takes up residence in the new, state-of-the-art Integrative Genomics Building (IGB) along with the U.S. Department of Energy Systems Biology Knowledgebase (KBase) to expand the frontiers of energy and environmental science in partnership with the worldwide community of researchers. Will you join us and be a critical part of the next ground-breaking discoveries in the public interest?
JGI is comprised of highly-skilled and diverse talent founded on a culture of scientific excellence, trust, curiosity, passion, and collaboration.
Working at Berkeley Lab has many rewards including a competitive compensation program, excellent health and welfare programs, paternal leave, a retirement program that is second to none, and outstanding employee development opportunities. To view information about the many rewards that are offered at Berkeley Lab- Click Here.
As part of the Joint Genome Institute (JGI) Division at Berkeley Lab, the Blaby group seeks to test and validate the use of optimal experimental design (OED) mathematical approaches for the redesign of biological systems. This project will deliver an experimental pipeline for targeted bioenergy/bioproduct outcomes by validating the mean objective cost of uncertainty (MOCU)-based experimental design via microbial strain engineering. This OED framework will simultaneously refine metabolic models and accelerate the search for strains with desired characteristics with reduced cost. You will interact closely with a team of mathematical/computational scientists to design genome manipulations; design and execute assays to assess the consequence of engineering to iterate with collaborators; and develop the necessary approaches to translate the advancements made here to additional microbial systems.
What You Will Do:
Work closely with other project team members to iteratively engineer microbial systems as guided by OED approaches as part of a design-built-test-learn cycle.
Work with a multi-disciplinary team of mathematicians and computer scientists to develop novel approaches to guide and test biological redesign strategies.
Design and perform engineering (gene manipulation, genome editing) of microbial systems.
Develop and perform biochemical assays, 'omic analyses.
Develop and translate findings to additional and possibly non-model systems.
Analyze, interpret and communicate findings in regular group meetings and project team conference calls.
Keep precise and detailed laboratory notebooks, maintain and manage all resources (eg vectors, strains, digital data) generated throughout the project.
Manage relationships with our collaborators.
Communicate findings via publications and national meetings.
What Is Required:
Ph.D. degree in the relevant fields in Molecular Biology, Microbiology, or Biochemistry.
Strong motivation to contribute to developing the areas of research under the DOE mission.
Detailed knowledge of genome engineering approaches.
Motivation to work independently.
Ability to successfully work in a dynamic team environment.
Strong written and oral communication skills.
Additional Desired Qualifications:
Experience of high throughput assay development and laboratory automation systems (liquid handlers, robotic colony pickers etc).
Experience in a range of microbial organisms (eg Gram negative, positive, microalgae etc).
The posting shall remain open until the position is filled.
This is a full time, 1 year, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 4 years of paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.
Full-time, M-F, exempt (monthly paid) from overtime pay.
This position is represented by a union for collective bargaining purposes.
Salary will be predetermined based on postdoctoral step rates.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at DOE Joint Genome Institute (JGI) -- 2800 Mitchell Dr., Walnut Creek, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with thePay Transparency Nondiscrimination Provisionunder 41 CFR 60-1.4. Clickhere to view the poster and supplement: "Equal Employment Opportunity is the Law."
Internal Number: 88343
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.