Laboratory of Clinical Immunology and Microbiology (LCIM)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institutes of Health (NIH)
The Neuroimmunological Diseases Section (NDS) of LCIM, NIAID Division of Intramural Research (DIR) is seeking a bioinformatics postdoctoral researcher.
The mission of NDS is to improve understanding of the mechanisms in central nervous system (CNS) injury, neuroprotection, and repair leading to effective treatments or cure of neuroimmunological diseases, especially multiple sclerosis (MS).
The postdoctoral fellow will use and develop advanced statistical and machine learning methodologies to analyze existing and to-be-collected quality-controlled and curated multimodal longitudinal patient data from NDS clinical protocols to construct statistical models of clinical utility. These may include
Genetics: whole exome sequencing and whole genome single nucleotide polymorphism (SNP) arrays
Proteomics: More than 5,000 proteins measured in cerebrospinal fluid (CSF) and serum
Cellular: multicolor flow cytometry data in CSF and serum
Quantitative imaging: brain MRI and optical coherence tomography and extensive clinical data, including fully digitalized neurological examinations and extensive quantitative data collected using smartphones
The fellow will benefit from a dynamic learning environment with a strong emphasis on reproducible science (including validation of derived models in independent cohorts), a multidisciplinary team of clinicians and scientists, strong domain-expertise guidance, and access to NIH state-of-the-art resources and support.
HHS, NIH, and NIAID are equal opportunity employers.
D. or equivalent degree in bioinformatics, biostatistics, biomathematics, or a related field with a strong computational component
Documented experience performing advanced statistical analyses on large, complex datasets in a programming language such as R and/or Python
Creative thinking, self-motivation, a strong work ethic, and an interest in developing and applying statistical methodologies to solving clinically relevant questions
Ability to collaborate with a multidisciplinary team of researchers and clinicians from NIH and outside collaborators
Experience, or interest in, applying Linux batch scripts in a high-performance computing environment
Experience querying data from relational database systems
Strong written and oral communication skills
About Laboratory of Clinical Immunology and Microbiology (LCIM)
A part of the U.S. Department of Health and Human Services, NIH is the largest biomedical research agency in the world. NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.
NIH provides leadership and direction to programs designed to improve the health of the Nation by conducting and supporting research:
in the causes, diagnosis, prevention, and cure of human diseases;
in the processes of human growth and development;
in the biological effects of environmental contaminants;
in the understanding of mental, addictive and physical disorders; and
in directing programs for the collection, dissemination, and exchange of information in medicine and health, including the development and support of medical libraries and the training of medical librarians and other health information specialists.
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