1) Computational Biology - Analyst - Scientific Project Strategy : Analyze multiple projects and contribute to workplan strategies for numerous intermediate steps: tasks, timing and specific deliverables. - Business Project Strategy: Interface with the Project Manager and strategize on efficient ways to accomplish deliverables with the most efficient use of resources, time and budget. Continually look for ways to enhance quality of work for minimal budget impact and maintain the project management timeline enforced by the sponsor. - Presents results both in-person and as supporting backup for others when they present results to sponsors.
2) Scientific Contributor to Pharma Industry Bilateral Collaborations and Federally-Funded Grants - Computational Strategy and Biological Interpretation: Function as part of joint team of computational biologists and bioinformaticians from both the Kretzler Lab, UMich Genetics and the Pharma Sponsor to formulate the most logical investigations and analyses to perform, as well as provide interpretation of bioinformatic results on a biological level to provide biological meaning to the reams of data generated. - Sponsor-facing Presentation of Data: Presents bioinformatic and computational biology approaches to Pharma sponsors and manages questions, justifies approaches and provides spontaneous suggestions on how to improve the overall project by modifying either the scientific question asked, or the technical/analytic strategy proposed.
3) Overall Kretzler Lab Strategy Task Force: Leads or contributes heavily to the overall Kretzler Lab strategy formulation on a semi-annual basis: Follows scientific market research on trends in both the basic science and industry domains. Suggests ways to maintain the Lab's cuttingedge approach to performing the bioinformatic analyses and biological interpretation that will ensure the Lab can propose value that will attract extensive federal funding and Industry sponsorship.
4) Publication: Contributes to numerous papers as part of the Kretzler lab, often writing Methods sections and generating meaningful figures. Grant Authorship: Contribute to strategy concerning grant submission for both large Federal Grant proposals, as well as smaller, Industry sponsorship proposals.
5) Primary Duties for Computational Genetics Analysis: - Continued analysis of the 30X WGS data set for novel CNVs potentially associated with NS. - Develop and deploy a variant browser for 30X WGS data and its database back-end infrastructure. - Provide ancillary bioinformatics support to genomics analysis projects including annotating and querying variant calls (eQTLS, Hi-C, etc...). - Identifying and maintaining most cost-effective storage solutions for large-scale genomics data cohorts. - Developing pipelines that leverage High Performance Computer (HPC) cluster resources to speed up analysis.
6) Analysis of proteomics data: - Development and maintenance of novel software tools to advance research projects for medical research staff. Writing custom software that fills a niche not met by any of the publicly available tools. - Educating and training research staff on proteomics analysis methods. - Using Amazon AWS for deployment of web-based services. Setting up and using Amazon’s AWS services. This can include the sharing and downloading data from collaborators/companies as well as websites for public/private use. Doing this in conjunction with the software team.
Ph.D. 5 years Post-Doctoral research experience - Life Sciences and Bioinformatics Analysis Techniques. 10 years experience as a Team Scientist in Academic environment working with large Pharma and midsized companies.
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A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.