Rutgers, New Jersey Medical School, Department of Obstetrics, Gynecology and Women's Health seeks a highly motivated Research Associate II to join a multi-center collaboration established to investigate the therapeutic potential of drugs that have activity against endometrial cancer. One of our primary focuses is on the Notch pathway.
Carcinoma of the endometrium is the most common malignancy affecting the female reproductive tract in the US and is on the rise. Notch signaling is an evolutionarily conserved pathway involved in cell fate determination during development, differentiation and stem cell renewal. Notch signaling is involved in tumor and tissue angiogenesis in multiple organs. Previous studies suggest that Notch signaling is aberrant in endometrial cancer. Our primary work focuses on the interaction between Notch and other angiogenic pathways in endometrial cancer. We will evaluate early drug development strategies in our models and other targets. Under the direction of the Chair of the Department, the Research Associate will be expected to further advance our understanding of mechanisms by which Notch interacts with other angiogenic pathways in the development, progression and recurrence of endometrial cancer. The Research Associate will also be exploring other targets of interest as part of the research team.
Works independently to further advance our understanding of mechanisms underlying endometrial cancer progression and recurrence.
Conducts a continuous program of research and development. Performs hypothesis driven experiments to advance our line of investigation and to generate preliminary data needed to support new and robust applications by the Principal Investigator and collaborators for funding from the NIH and other sources.
Keeps detailed records of each experimental protocol.
Generates, compiles, analyzes and presents data with appropriate conclusions and recommendations.
Prepares manuscripts for peer-review and publication.
Responsible for hands on teaching and instruction of technicians.
Assists in the implementation of the programs and projects in special areas of interest to the OBGYN Department, including but not limited to cardiovascular disease, cancer and related subspecialties.
Assists with teaching basic lab techniques to various trainees in the laboratory, including college students, medical students,graduate students, clinical residents and fellows in the Department of OBGYN and Women's Health.
Reports to the Principal Investigator on the daily activities of postdoctoral fellows, graduate students and technical staff.
Develops and maintains databases for mouse inventory and cross references to secondary databases, linking files for all data collected on each animal. Anticipates future needs for data exchange, analysis and submission. Assures that database allows for specialized feature discovery, parallel statistical analysis, and efficient indexing.
Responsible for ensuring smooth operation of the laboratory and general lab maintenance. Indirectly supervises technicians for the following: maintaining and cleaning equipment, ordering lab supplies, processing of orders or invoices, and ensuring compliance with institutional regulatory procedures.
Minimum Education and Experience:
Ph.D. Degree or equivalent in Molecular Cell Biology, Biochemistry or a relevant science, or a Master’s Degree in a relevant science plus three (3) years of laboratory experience with a strong background in cancer biology, immunology, molecular biology and use of animal models.
Applicants possessing a degree in Social Work must have an active New Jersey certification/licensure as required by the State Board of Social Work.
Required Knowledge, Skills, and Abilities:
Must possess good organization and documentation skills, and must demonstrate good communication skills in English.
Must be comfortable working quickly and accurately in a stressful, deadline driven work environment.
Must be able to prioritize and quickly learn new techniques and work independently, with careful attention to detail.
Experience using transgenic mouse models or other mammalian models for protein biochemistry (ELISA and Western Blot) and molecular biology (RNA extraction, quantitative RT-PCR, array analysis) studies.
Previous experience in endocrinology and gene expression studies, experience with morphologic studies using immunohistochemistry/immunofluorescence and microscopy, experience using confocal microscopy and our FACS and experience with in vitro cell culture systems.
Must be able to communicate effectively.
Valid driver's license.
It is preferred that the applicant has experience with flow cytometry, morphologic studies using immunohistochemistry, confocal laser microscopy and digital imaging.
Physical Demands and Work Environment:
Must be able to accurately and quickly read and interpret data on computer screens, written reports, graphs, and tables.
Must be able to go to laboratories and speak with investigators and scientific support staff about research data.
Must be able to use research equipment, computers, telephones, e-mail, fax machines, scanning devices, handheld communication devices, and similar office equipment without delay.
Must be comfortable with stress and perform well under multiple deadlines.
This position may involve prolonged standing, walking and sitting, as well as use of research instruments. Some stooping, reaching, climbing and bending. Occasional lifting of 20 pounds to a height of 6'6 feet.
Hearing and speech capabilities necessary to communicate with other researchers and staff in person, on the telephone and by e-mail. Vision capable of viewing computer monitors, charts, forms, text and numbers for prolonged periods.
Must be available to work flexible hours, including some weekends and holidays.
Salary: Maximum authorized hiring amount $56, 372
Posting Number: 19ST2888
Location: Newark (RBHS)
Internal Number: 93747
About Rutgers University
Rutgers, The State University of New Jersey, is a leading national public research university and the state's preeminent, comprehensive public institution of higher education. Rutgers is dedicated to teaching that meets the highest standards of excellence; to conducting research that breaks new ground; and to turning knowledge into solutions for local, national, and global communities. As it was at our founding in 1766, the heart of our mission is preparing students to become productive members of society and good citizens of the world. Rutgers teaches across the full educational spectrum: preschool to precollege; undergraduate to graduate and postdoctoral; and continuing education for professional and personal advancement. Rutgers is New Jersey's land-grant institution and one of the nation's foremost research universities, and as such, we educate, make discoveries, serve as an engine of economic growth, and generate ideas for improving people's lives.